Last edited by Mutilar
Sunday, May 3, 2020 | History

6 edition of Renal Ischemia / Reperfusion Injury in Diabetes found in the catalog.

Renal Ischemia / Reperfusion Injury in Diabetes

by Jan Melin

  • 396 Want to read
  • 31 Currently reading

Published by Uppsala Universitet .
Written in English

    Subjects:
  • Internal Medicine,
  • Medical

  • Edition Notes

    SeriesComprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, 1131
    The Physical Object
    FormatPaperback
    Number of Pages55
    ID Numbers
    Open LibraryOL12854479M
    ISBN 109155452647
    ISBN 109789155452643

      Diabetes could aggravate ischemia/reperfusion (I/R) injury, but the underlying mechanism is unclear. In this study, we aimed to investigate whether diabetes exacerbates renal I/R injury and its possible mechanism.   Acute renal failure complicates renal ischemia–reperfusion (I/R) owing to reactive oxygen species production. Atorvastatin (ATO) has anti-inflammatory and antioxidant properties. The current study investigated whether ATO alleviated damage induced by renal I/R injury in nondiabetic versus diabetic rat by: 3.

    Exenatide protects renal ischemia reperfusion injury in type 2 diabetes mellitus Jitendra Vaghasiya, Navin Sheth 1, Yagnik Bhalodia 2, Malaviya Shailesh 2, Nurudin Jivani 2.   The new reassortant of the swine flu virus A(H1N1)pdm09, which emerged in , overcame the species barrier and caused the pandemic.

      Background and aims: Diabetic kidney is more sensitive to ischemia/reperfusion (I/R) injury, which is associated with increased oxidative stress and impaired nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling. Melatonin, a hormone that is secreted with the rhythm of the light/dark cycle, has antioxidative effects in reducing acute kidney injury (AKI).Cited by: 5. In this study, we developed a nonhuman primate model of renal ischemia-reperfusion injury (IRI), which is the most common cause of AKI in human [19]. We used this model to confirm whether diabetes can increase the susceptibility to AKI and also to evaluate the efficacy of human bone marrow-derived MSCs (hBM-MSCs) in reducing renal IRI. 2.


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Renal Ischemia / Reperfusion Injury in Diabetes by Jan Melin Download PDF EPUB FB2

Diabetes aggravates renal ischemia-reperfusion injury by repressing mitochondrial function and PINK1/Parkin-mediated mitophagy. Yang YY(1), Gong DJ(1), Zhang JJ(1), Liu XH(1), Wang L(1). Author information: (1)Department of Urology, Renmin Hospital of Wuhan University, Wuhan, Hubei, : Yuan-Yuan Yang, Dao-Jing Gong, Jian-Jian Zhang, Xiu-Heng Liu, Lei Wang.

Diabetic patients are more susceptible to renal ischemia/reperfusion (I/R) injury (RI/RI) Renal Ischemia / Reperfusion Injury in Diabetes book have a poor prognosis, but the underlying mechanism remains unclear.

The present study aimed to examine whether diabetes could worsen acute kidney injury induced by I/R in rats and clarify its : Dao-Jing Gong, Lei Wang, Yuan-Yuan Yang, Jian-Jian Zhang, Xiu-Heng Liu. renal ischemia-reperfusion injury (IRI), which is the most common cause of AKI in human [19].

We used this model to confirm whether diabetes can increase the susceptibility to AKI and also to evaluate the efficacy of human bone marrow-derived MSCs (hBM-MSCs) in reducing renal IRI.

Materials and Methods by: 3. Diabetes could aggravate ischemia-reperfusion (I/R) injury, but the underlying mechanism is unclear. In the present study, we aimed to investigate whether diabetes exacerbates renal I/R injury and its possible : Yuan-Yuan Yang, Dao-Jing Gong, Jian-Jian Zhang, Xiu-Heng Liu, Lei Wang.

Renal Ischemia-Reperfusion Injury in a Diabetic Monkey Model and Therapeutic Testing of Human Bone Marrow-Derived Mesenchymal Stem Cells. 1Department of Surgery, Division of Transplantation, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, SeoulRepublic of by: 3.

kidneys. Insulin treatment before ischemia, but not after, reduces the renal injury in DM rats. Studies using a more reliable administration of CoPP are required to decide if induction of HO-1 protects against renal I/R injury in DM Key words: diabetes mellitus, ischemia/reperfusion, rat, end-stage renal.

Group I: nondiabetic sham, Group II: diabetic sham, Group III (diabetic IR): renal ischemia/reperfusion injury in diabetic rats group, and Group IV (diabetic IR + LIPC): renal ischemia/reperfusion injury in diabetic rats group and local ischemia preconditioning; Mann-Whitney test was conducted to compare two independent groups.

Values are mean ± 1 SD, median (minimum-maximum).Cited by: 5. Renal Ischemia-Reperfusion Injury in a Diabetic Monkey Model and TherapeuticTesting of Human Bone Marrow-Derived Mesenchymal Stem Cells. Lee KW(1), Kim TM(2), Kim KS(1), Lee S(3), Cho J(4), Park JB(1), Kwon GY(4), Kim SJ(1).Cited by: 3.

Diabetes mellitus (DM) is one of the leading causes of end stage renal failure. An increased susceptibility to renal ischemia/reperfusion (I/R)-injury was found in DM rats. Unilateral renal ischemia for as short as 20 minutes led to an irreversible progressive injury in DM kidneys, whereas the injury in non-DM kidneys was almost : Jan Melin.

Renal Ischemia/Reperfusion Injury in Diabetic Rats: The Role of Local Ischemic Preconditioning Article (PDF Available) in BioMed Research International (9) January with 67 Reads.

Renal ischemia-reperfusion (IR) injury is the most frequent cause of AKI (1, 39). The relative risk for end-stage renal disease (ESRD) in patients with CKD after AKI is 13 times greater than in patients with normal renal function (13, 46).

Numerous mechanisms have been reported to enhance the susceptibility to AKI in elderly patients with by: 3. Renal Ischemia/Reperfusion Injury in Diabetic Rats: the risk of renal injury induced by ischemia/reperfusion in diabetic rat model.

Introduction Diabetes mellitus (DM) is a common and. Greite, et ischemia-reperfusion injury causes hypertension and renal perfusion impairment in the CD1 mice which promotes progressive renal fibrosis Am.

Physiol. Renal Physiol., (5) (), pp. FF, /ajprenalAuthor: Gerald J. Maarman. Ischemia/reperfusion injury (IRI) is caused by a sudden temporary impairment of the blood flow to the particular organ.

IRI usually is associated with a robust inflammatory and oxidative stress response to hypoxia and reperfusion which disturbs the organ by:   Diabetes mellitus is a major risk factor for acute kidney injury (AKI). Here, we hypothesized that suppression of autophagic response underlies aggravation of renal ischemia/reperfusion (I/R Cited by: 9.

Diabetes mellitus (DM) is one of the leading causes of end stage renal failure. An increased susceptibility to renal ischemia/reperfusion (I/R)-injury was found in DM rats. Unilateral renal ischemia for as short as 20 minutes led to an irreversible progressive injury in DM kidneys, whereas the injury in non-DM kidneys was almost reversible.

The present study examined the effects of aging and diabetes on the severity of renal ischemia reperfusion (IR) injury in Sprague Dawley (SD) andtype-2 diabetic (T2DN) rats. T2DN rats develop diabetes at 3 months of age andprogressive proteinuria and diabetic nephropathy as they age from 6 to 18 by: 3.

The incidence and severity of acute kidney injury is increased in patients with diabetes and with aging. However, the mechanisms involved have not been clearly established.

The present study examined the effects of aging and diabetes on the severity of renal ischemia-reperfusion (IR) injury in Sprague-Dawley (SD) and type 2 diabetic (T2DN) by: 3. Sustained delivery of insulin-loaded block copolymers: Potential implications on renal ischemia/reperfusion injury in diabetes mellitus Author links open overlay panel Fei Tong a b Xiangyuan Tang a Lei Luo a Xin Li a Wenquan Xia a Chao Lu a Daojun Liu aCited by: 2.

Diabetes mellitus (DM) is one of the leading causes of end stage renal increased susceptibility to renal ischemia /reperfusion (I/R)-injury was found in DM eral renal ischemia for as short as 20 minutes led to an irreversible progressive injury in DM kidneys, whereas the injury in non-DM kidneys was almost reversible.

The renal I/R injury was characterized by anuria. Home > Journals > Canadian Journal of Physiology and Pharmacology > List of Issues > Vol Preconditioning with atorvastatin against renal ischemia–reperfusion injury in nondiabetic versus diabetic rats.

Canadian Journal of Physiology and Pharmacology,97(1): 1 Cited by: 3.Renal ischemia/reperfusion (I/R) injury (RI/RI) is a common pathophysiologic phenomenon, and it is a complex and important pathological process with many factors involved.

I/R damage is one of the underlying causes of acute renal failure and reactive oxygen species (ROS) play important parts in mediating tissue damage during I/R damage. Oxidative stress is generated via an imbalance Cited by: 2.into renal ischemia/reperfusion (i/r) injury (ri/ri) ().

Physicians and scientists have made efforts in identifying novel therapeutic targets to mitigate the complications of dM.

Signaling pathways have evolved over years in many species (6), for instance during kidney development. Wnt signaling has been shown to function in renal injury (7,8).